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There is no simple solution to the obesity epidemic. There are several resources, programs, and guides that are geared to help people live a healthy lifestyle through healthy eating and regular physical activity. Now, new research shows that a stomach-specific protein plays a critical role in the progression of obesity, and could potentially lead to
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Millimeter-wide 3-D models that mimic vital aspects of the human nervous system have been developed in a step that could accelerate drug research for neurological conditions such as multiple sclerosis (MS). The models will be used to study myelin. Researchers say the models are the most natural representation of human myelination developed in a lab
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There is little doubt within the scientific community of the immense impact that next-generation sequencing (NGS) has had on translational research. Techniques like liquid biopsy have allowed investigators to harness the power of NGS to identify genetic mutations from blood samples noninvasively. Identifying such mutations enables earlier diagnosis of cancer and can inform treatment decisions
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The superbug Pseudomonas aeruginosa, which can cause lung infections in people on ventilators in intensive care units. [Imperial College London] Work by scientists at Imperial College London and the University of Texas has revealed how a key “last resort” antibiotic kills bacteria. The research has revealed how the antibiotic, colistin, punches holes in both of
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Bowel cancer survival rates could be improved if chemotherapy drugs were delivered via tiny nanoparticles to the diseased organs rather than oral treatment. That’s the conclusion of Indian and Australian scientists who have undertaken a study using nanoparticles to target bowel cancer, the third most common cancer in the world and the second most deadliest.
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A cryomicroneedle patch ready for deployment. [Chang et al. /DOI number: 10.1038/s41551-021-00720-1] A research team led by City University of Hong Kong (CityU) scientists has developed a new generation of microneedle technology that allows the intradermal delivery of living cells, in a minimally invasive manner. Their studies demonstrated that using the new cryomicroneedle technology to delivery
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A mini T-shirt demonstrates the photosynthetic living materials created in the lab of University Rochester biologist Anne S. Meyer and Delft University of Technology bionanoscientist Marie-Eve Aubin-Tam using 3D printers and a new bioink technique. [University of Rochester] The materials that make up our environment such as steel, plastic, glass, and concrete help us in
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As the COVID-19 pandemic continues, the pace of vaccine development has surpassed anyone’s wildest expectations. Unfortunately, drug development for treatments has not kept the same pace. Indeed, there are still very few effective treatments for COVID-19. Now, a collaboration between four research institutes has identified the antimalarial drug amodiaquine as a potent inhibitor of SARS-CoV-2
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Diet determines the placement of methylation signatures like post-its at specific sites on a messenger RNA (mRNA) marking the molecules for degradation, a new study on the microscopic model worm, Caenorhabditis elegans, reveals. The findings of this collaborative study by scientists from the University of Geneva (UNIGE), Switzerland, and the Norwegian University of Science and Technology
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Although the number of Americans vaccinated against COVID-19 rises every day, testing remains a key component to the country’s public health effort to thwart the spread of the virus. Testing is particularly important as more children—who are currently ineligible for a vaccine—return to school for in-person learning. Today, Ginkgo Bioworks announced a collaboration with Quest
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Researchers published a study “Four distinct trajectories of tau deposition identified in Alzheimer’s disease” in Nature Medicine that shows how the tau protein spreads in AD according to four distinct patterns that lead to different symptoms with different prognoses of the affected individuals. “Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the
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Retron-based genome editing has been inviting comparisons with CRISPR-based genome editing, especially since researchers have learned that retrons, like CRISPR systems, function as a sort of immune system in bacteria. However, the comparisons may be a little premature. Retron-based genome editing has yet to work in mammalian cells. Nonetheless, retrons have already been shown to
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University of Tokyo researchers and colleagues at the RIKEN Research Institute have compiled a first-of-its-kind genetic database for autoimmune and autoinflammatory diseases. It’s hoped that the resource will offer up new insights into how immune disorders develop, and potentially aid in drug discovery. Scientists also hope that the atlas of immune-related genome data may eventually
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New York Genome Center (NYGC) and New York University (NYU) scientists report that they have developed a genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. The new platform could help researchers study how links between genetic changes and chromatin accessibility may contribute to diseases such as cancer. Inspiration for
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Timothy J. Miller, PhD, Forge Biologics CEO, president, and co-founder, Gene therapy-focused CDMO Forge Biologics has closed on a $120 million Series B financing, saying the proceeds will accelerate its planned expansion of adeno-associated virus (AAV) manufacturing capabilities. The company operates a 175,000-square-foot cGMP facility in Columbus, OH, dedicated to AAV viral vector manufacturing, which
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