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Translate Bio CEO Ronald C. Renaud Jr. discusses his company, its mRNA platform, and its partnership with Sanofi in COVID-19 and other diseases as a guest in September 2020 on “GEN Live,” GEN’s monthly live-streaming video discussion series. Sanofi is acquiring its COVID-19 vaccine collaboration partner Translate Bio for approximately $3.2 billion, the companies said
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A U.K.-based consortium consisting of BiologIC Technologies, Biopharm Services, CPI, Pall, and SCIEX launched a project to develop automated manufacturing controls for use in the manufacture of biologics. The project, worth a total of £3.1million, including equipment contributions, has received support from Innovate UK to platform this advanced technology. While the accelerated development and scale-up
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Ovarian cancer is a group of diseases that originates in the ovaries, or in the related areas of the fallopian tubes and the peritoneum. It is the second most common gynecologic cancer in the United States. The most common tumor type is high-grade serous carcinoma, occurring in about 70% of ovarian cancer cases. UT Southwestern
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Source: Photo by thom masat on Unsplash Researchers at the University of California, San Francisco (UCSF), have devised a two-drug therapeutic approach for alcohol use disorder (AUD), which studies in mice suggest doesn’t have the side effects or complications associated with current treatment regimens, and which could feasibly be applicable to other drugs that are
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After skin cancer, the most common cancer in men is prostate cancer. Although often successfully treated, some prostate cancers remain recalcitrant. Now, a team at the University of Michigan Rogel Cancer Center has uncovered that targeting the lipid kinase PIKfyve may be an effective treatment strategy alone—or in combination with immunotherapies—against the most challenging type
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If you haven’t started already, it’s time to start preparing for back to school! This time of the year always manages to creep up on us, how about you? Which is why we’re delving into our vast content library to provide you with a little back to school quilting inspiration. If you’re looking to make
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The FDA on Friday expanded the emergency use authorization (EUA) it granted in November to Regeneron Pharmaceuticals for its two-antibody “cocktail” REGEN-COV™ (casirivimab and imdevimab) to allow its use in patients seeking protection from COVID-19 following exposure to someone infected with SARS-CoV-2. The expanded EUA also authorizes REGEN-COV for people deemed at high risk of
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Hearing loss is one of the most common disabilities in the United States. It can be caused by the effects of aging, genetic mutations, environmental stress, or exposure to drugs such as platinum-based chemotherapy drugs. Researchers have been focusing their attention on several pathways with implications in development and regeneration. Now, researchers from the USC
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Biologists at the Washington University in St. Louis are using comparative metabologenomics to try to uncover what may be “silencing” Streptomyces (the bacteria responsible for the first bacterial antibiotics to treat tuberculosis back in the 1940s) and preventing it from producing desirable compounds encoded by its genes. “We examined genetic differences across the genomes of Streptomyces while at
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As stubborn as they are common, urinary tract infections (UTIs) have attracted intense scrutiny, but much about them remains hidden. Scientists know that they begin with intracellular bacterial communities (IBCs), and that these communities, which grow inside the cells lining the bladder’s wall, burst free, unleashing an infectious cascade that eventually reaches the bladder’s deeper
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Using advanced imaging technology, Mayo Clinic scientists have provided a better understanding of the BRCA1-BARD1 protein complex, which is often mutated in patients with breast or ovarian cancer. Their paper (“Mechanisms of BRCA1–BARD1 nucleosome recognition and ubiquitylation”), published in Nature, identifies aspects of how BRCA1-BARD1 functions, supporting future translational research, cancer prevention efforts and drug
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Eli Lilly’s Loxo Oncology at Lilly research group will apply Kumquat Biosciences’ small molecule immuno-oncology (I/O) platform to discover, develop, and commercialize potential novel drugs against cancer, through a collaboration that could generate more than $2 billion for the San Diego biotech. The collaboration is intended to yield new small molecule drugs that stimulate tumor-specific immune
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Researchers headed by a team at the Perelman School of Medicine, University of Pennsylvania, have demonstrated how treating obese mice with a cytokine called thymic stromal lymphopoietin (TSLP) triggers significant abdominal fat and weight loss. The team’s studies found that, unexpectedly, the fat loss was not associated with decreased food intake or faster metabolism. Rather, administering
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A rare childhood disorder that mimics inflammatory bowel disease termed “Deficiency in ELF4, X-linked,” or DEX for short, has been recently identified. Using genome sequencing, Yale researchers reported they have uncovered the underlying genetic cause of the disorder. Their work may help identify the roots of a host of other inflammatory and autoimmune disorders. The
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Farnesol, an antimicrobial compound found in herbs, fruits, and fungi prevents and reverses brain damage linked to Parkinson’s disease (PD), an international team led by scientists at Johns Hopkins University School of Medicine claims, based on mouse studies. Tremors, muscle rigidity, confusion, and dementia—the hallmarks of PD—are caused by the loss of neurons that secrete
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A meta-analysis of nearly 200,000 men has revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors (TGCT). The findings increase by 40% the number of regions known to be associated with this type of cancer. The multi-institutional meta-analysis was conducted by researchers from the international TEsticular CAncer Consortium (TECAC),
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The mesencephalic locomotor region, which is part of the midbrain, is involved in regulating walking and other forms of locomotion in many animal species. But the function of neurons in this area of the brain remains controversial. Researchers led by Silvia Arber, PhD, a professor and group leader at the FMI and the Biozentrum of
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Nanobodies, or single-domain antibodies, are smaller and simpler than conventional antibodies, but they have huge potential. Since this potential is being explored by multiple research teams, any one team has difficulty producing standout work. Yet researchers from two Göttingen institutions, the Max Planck Institute for Biophysical Chemistry and the University Medical Center, assert that they
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