Month: April 2021

Retron-based genome editing has been inviting comparisons with CRISPR-based genome editing, especially since researchers have learned that retrons, like CRISPR systems, function as a sort of immune system in bacteria. However, the comparisons may be a little premature. Retron-based genome editing has yet to work in mammalian cells. Nonetheless, retrons have already been shown to
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University of Tokyo researchers and colleagues at the RIKEN Research Institute have compiled a first-of-its-kind genetic database for autoimmune and autoinflammatory diseases. It’s hoped that the resource will offer up new insights into how immune disorders develop, and potentially aid in drug discovery. Scientists also hope that the atlas of immune-related genome data may eventually
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New York Genome Center (NYGC) and New York University (NYU) scientists report that they have developed a genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. The new platform could help researchers study how links between genetic changes and chromatin accessibility may contribute to diseases such as cancer. Inspiration for
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A historic, Greek Revival townhouse that once belonged to Leslie J. Garfield, founder of the eponymously named brokerage and known as the “dean of townhouses,” has sold for $15.25 million, Gimme Shelter has learned. The deed has not yet hit public records. Garfield used this home as an investment property and never lived there. We
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Timothy J. Miller, PhD, Forge Biologics CEO, president, and co-founder, Gene therapy-focused CDMO Forge Biologics has closed on a $120 million Series B financing, saying the proceeds will accelerate its planned expansion of adeno-associated virus (AAV) manufacturing capabilities. The company operates a 175,000-square-foot cGMP facility in Columbus, OH, dedicated to AAV viral vector manufacturing, which
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The brain’s lymphatic drainage system removes cellular debris and other waste. The system was recently discovered in 2015 by Jonathan Kipnis, PhD, the Alan A. and Edith L. Wolff distinguished professor of pathology and immunology, and a BJC investigator at Washington University in St. Louis. Now new research by Kipnis and colleagues suggest that immunotherapies
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Studies in mice by researchers at the University of Melbourne and Monash University, have uncovered a mechanistic link between stress and weakened immunity. Their studies found under conditions of stress the neurotransmitter noradrenaline (NA)—which plays a key role in the fight-or-flight stress response—impairs immune responses by inhibiting the movements of various white blood cells in
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