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Researchers from the Université de Montpellier, France, and the University of Pittsburgh, have published a study (“Mycobacteriophage-antibiotic therapy promotes enhanced clearance of drug-resistant Mycobacterium abscessus”) in Disease Models & Mechanisms that describes the antibacterial effects of treating infections caused by the antibiotic-resistant bacteria M. abscessus with a bacteriophage and an antibiotic. “Infection by multidrug-resistant Mycobacterium abscessus is increasingly
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Phytoplasma effector SAP05 induces witches’ broom in Arabidopsis [John Innes Centre] The results of studies in a plant model organism suggest that a newly discovered mechanism used by parasitic bacteria to slow down plant aging may point to a novel approach to protecting disease-threatened food crops. The research, headed by scientists at the John Innes
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New research suggests that the presence of certain bacteria in a gut biome may be an indicator of colon polyps that will become cancerous. Researchers from the University of Washington School of Medicine analyzed 40 patients who had undergone colonoscopies and had biopsies taken near polyps to identify bacteria and compare with those who were
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An innate sensing and signaling mechanism triggered in people by a broad array of environmental allergens including fungi, insects, and mites, has been discovered in new research led by scientists at Cincinnati Children’s Hospital Medical Center. The built-in rapid reaction system may hold the key to understanding and treating human allergies. Studies in immunology over
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With the children of the company’s co-founders right up front, the Ginkgo Bioworks team rang the bell of the New York Stock Exchange this morning, taking the synthetic biology company public. The synthetic biology powerhouse became a public company through a merger with a special purpose acquisition company (SPAC) that values the company at $15
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Chloroplasts (magenta) in leaves expressing a green fluorescent protein. The DNA encoding for the protein was delivered by targeted nanomaterials without mechanical aid by applying a droplet of the nano-formulation to the leaf surface. [Israel Santana/UCR] University of California-Riverside (UCR) researchers say they are studying whether they can turn edible plants like lettuce into mRNA
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A new study may help researchers decide what proteins to include in vaccines against cancer. Cancer cells display unique mutated proteins called neoantigens on their surfaces. Fragments of certain neoantigens when injected into the body can stimulate the body’s immune system to annihilate the tumor, acting like a vaccine. Such cancer vaccines have not yet
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The relationship between pancreatic cancer and inflammation has long been recognized. There have been many studies carried out to reveal the underlying mechanisms that contribute to tumorigenesis induced by inflammation, but the reasons behind this connection have remained unclear. Now, a new mouse study by researchers at the University of Texas MD Anderson Cancer Center
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Scientists at Stanford University School of Medicine have found that statins, a commonly prescribed type of cholesterol-lowering drug, may also be an effective, if unexpected, treatment for the inflammatory bowel disease, ulcerative colitis (UC). By tapping into publicly available datasets of anonymized patient health information, including transcriptomic data from ulcerative colitis samples, the team identified
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As we delve into fall, winter, and holiday quilting, it’s important that the tools that we’re working with on a daily basis – namely our trusty sewing machines – are in tip-top condition. This means a bit of seasonal sewing machine maintenance is in order. And lucky for you, we have an entire editorial team
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Scientists at Ohio State University provide evidence that members of a class of proteins called serine incorporator proteins, best known for curbing HIV infection also promote other antiviral activities that increase the production of type I interferons and proinflammatory cytokines. By promoting these signaling pathways of innate immunity, the SERINC restriction factors SERINC3 and SERINC5,
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Scientists at the Baylor College of Medicine say they have developed a technique for studying the role genes play on basic biology and disease that is easier, faster, and more efficient than current methodologies. Their drug-based genetic platform enables researchers to track genetic manipulations in the laboratory fruit fly (Drosophila melanogaster) without having to screen
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Theravance chairman and CEO Rick E. Winningham Intent on bouncing back from a pair of later-phase clinical trial failures, Theravance Biopharma said it will eliminate about 75% of its workforce—270 jobs—and slash its R&D budget next year through a restructuring that will refocus the company on respiratory drugs. Theravance said approximately 75% of the job
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Researchers at Case Comprehensive Cancer Center uncovered a potentially important role for the protein-coding gene, MYO10, in regulating genomic instability, and in tumor development and immune therapy response. Their findings suggest that levels of MYO10 may indicate which breast cancers are likely susceptible to immune checkpoint blockade (ICB). The team’s studies in cancer cells and
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Researchers at McMaster University have developed a sophisticated new tool that could help provide early warning of rare and unknown viruses in the environment and identify potentially deadly bacterial pathogens which cause sepsis, among other uses. Their findings are published in the journal Cell Reports Methods in a paper titled, “Probe design for simultaneous, targeted
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Aging brings with it thinner bones, more fractures, and an increased likelihood of osteoporosis. One reason for these aging ailments is the impaired function of the bone-marrow stem cells, which are required for the maintenance of bone integrity. Now, researchers have shown that changes in the epigenome are one reason for the reduction in stem
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Researchers led by scientists at the National Institute of Allergy and Infectious Diseases (NIAID) have developed antibodies that can simultaneously bind to two different antigens, targeting multiple regions of the SARS-CoV-2 spike protein. These bispecific antibodies successfully neutralize the original virus as well as the Alpha, Beta, Gamma, and Delta variants. Emerging SARS-CoV-2 variants of
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Astellas Pharma has acknowledged that a fourth boy has died in the troubled Phase I/II trial through which its Astellas Gene Therapies (formerly Audentes Therapeutics) has been evaluating its adeno-associated virus (AAV) gene therapy candidate AT132 in patients with X-linked Myotubular Myopathy (XLMTM). Unlike the other three boys who all died last year in the
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Researchers at UCL and MRC London Institute of Medical Sciences have demonstrated that reducing naturally occurring errors in protein synthesis improves both health and lifespan in different model organisms. The findings, reproduced in yeast, roundworms, and fruit flies, are the first to demonstrate a direct link between fewer protein mistakes and longevity. The study also
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Researchers are focusing on several major areas to improve cancer immunotherapy. Now, a team at Kyoto University report they have developed a synthetic molecule that can provide energy to anticancer immune cells, increasing their numbers and improving their longevity. Their findings are published in the journal Cell Chemical Biology in a paper titled, “Targeted epigenetic
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