1

The American Association for Cancer Research (AACR) annual meeting kicked off (virtually) this past weekend. On the first morning of the meeting, the synthetic biology company Synlogic presented data from the clinical trial testing their immunotherapy drug SYNB1891. The drug, a living biotherapeutic consisting of engineered bacteria that are injected intratumorally, is being developed for
0 Comments
Neurons run on calcium, which plays a dual role as a charge carrier and an intracellular messenger. Calcium signals regulate various developmental processes and have a key role in apoptosis, neurotransmitter release, and membrane excitability; calcium is also involved in memory formation, metabolism, and cell growth—making it quite the multitasker. Now using animal models, researchers
0 Comments
Scientists led by a team at the Whitehead Institute have developed a new gene editing technology, called CRISPRoff, which can be used to control gene expression with high specificity, while leaving the sequence of the DNA unchanged. Utilizing a programmable, epigenetic memory writer protein to silence gene expression, CRISPRoff is a highly specific method that
0 Comments
Zebrafish can heal their damaged hearts. Humans hearts retain scars of earlier injuries. In a new article published in the journal Science, titled “Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish,” scientists from the Victor Chang Cardiac Research Institute in Sydney report finding a new genetic switch that could help damaged human heart
0 Comments
The first, complete, telomere-to-telomere sequence of a human autosome has been completed. The sequence of chromosome 8 not only fills in the gap of more than three million bases missing from the current reference genome, but its DNA content and arrangement are of interest in an evolutionary context, in several immune and developmental disorders, and
0 Comments
Apply the following to make your franchise organization thrive. April 9, 2021 4 min read Opinions expressed by Entrepreneur contributors are their own. The following is an excerpt from Franchise Bible: How to Buy a Franchise or Franchise Your Own Business, Ninth Edition, which will be released April 20 through Entrepreneur Press. Pre-order now via Amazon | Barnes
0 Comments
The development of the brain during embryonic growth has garnered much attention from the neuroscience research community. However, the events that occur in the maturing brain after birth are less well understood. Now, a team has identified the microRNA-29 family to be “strikingly induced” during the late stages of brain maturation. In addition, they found
0 Comments
Established in 1982, Great Clips started franchising in 1983 and now has more than 4,000 locations throughout the United States and Canada. Usually located in strip malls, Great Clips hair salons are open evenings and weekends and do not require appointments. No hair-care experience is required for franchisees, who operate 5 to 6 units after
0 Comments
Scientists at University College London (UCL) have used artificial intelligence (AI) to identify three new multiple sclerosis (MS) subtypes from brain MRI scans. The researchers say the findings will help to identify those individuals with MS who are more likely to have disease progression, and could aid in more effective treatment targeting. Arman Eshaghi, MD,
0 Comments
Crohn’s disease is a type of inflammatory bowel disease (IBD) that causes inflammation of the digestive tract. Anti-inflammatory medications can greatly reduce its signs and symptoms and even bring about long-term remission and healing of inflammation. However, medications do not just target the digestive tract; they can affect the entire body creating the potential for
0 Comments
Cells from individuals with Major Depressive Disorder (MDD) were found to have higher than expected rates of methylation at specific sites on their DNA, when compared to cells from healthy individuals without MDD, according to a multidisciplinary team of University of California-San Francisco (UCSF) scientists, in collaboration with others. Methylation of particular sets of genes
0 Comments
Artios Pharma CEO Niall Martin, PhD Novartis has agreed to identify and validate next-generation DNA Damage Response (DDR) targets for precision cancer treatments using Artios Pharma’s discovery platform, through a collaboration that could generate more than $1.3 billion for Artios. The companies plan to discover and validate targets that enhance Novartis’ Radioligand Therapies (RLTs) through
0 Comments
Oxidative stress is caused by an imbalance between production and accumulation of oxygen reactive species (ROS) in cells and tissues. Manganese superoxide dismutase (MnSOD) is an antioxidant enzyme that protects the mitochondria from oxidative damage by using a mechanism involving electron and proton transfers to lower ROS levels in mitochondria. More than a quarter of
0 Comments
“We know there are developmental roots to major psychiatric disorders such as depression, schizophrenia, and bipolar disorder—and that these roots begin in fetal development. We also know these disorders are associated with abnormalities in brain circuitry that regulates stress—circuitry that is intimately tied to regulating our immune system,” says Jill M. Goldstein, PhD, founder and
0 Comments
Uptown Cheapskate is a resale store for young adults that buys and sells name-brand apparel, shoes and accessories. The company, based in Salt Lake City, Utah, started in 2008 and began franchising the same year. [embedded content] Fast-growing resale clothing franchise is looking for hungry entrepreneurs Take the thrift store experience where it’s never been
0 Comments
Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing (PANDORA) is a new RNA sequencing method developed by scientists from the University of California, Riverside (UCR). Unlike Pandora’s box which refers to a source of endless complications or trouble arising from a single, simple miscalculation—this Pandora, may be a source of opportunity as it can
0 Comments