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Scientists at Stanford University School of Medicine have found that statins, a commonly prescribed type of cholesterol-lowering drug, may also be an effective, if unexpected, treatment for the inflammatory bowel disease, ulcerative colitis (UC). By tapping into publicly available datasets of anonymized patient health information, including transcriptomic data from ulcerative colitis samples, the team identified
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As we delve into fall, winter, and holiday quilting, it’s important that the tools that we’re working with on a daily basis – namely our trusty sewing machines – are in tip-top condition. This means a bit of seasonal sewing machine maintenance is in order. And lucky for you, we have an entire editorial team
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This just in: Newsmax is expanding, doubling its Manhattan office space. The Florida-based conservative news service has leased a roughly 24,000-square-foot full floor at 805 Third Ave., between 49th and 50th streets. Newsmax signed a five-year deal for the 19th floor of the skyscraper in a direct deal with the building’s landlord, Cohen Brothers Realty
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These New Yorkers pay the mortgage on a seven-figure home every month — but they don’t own real estate. With uncertainty lingering over the future of the pandemic, financial markets and politics, many wealthy New Yorkers are shunning the housing market and opting instead to rent super luxury skypads. Recently, longtime Virginia resident Dr. John
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Yes, Queens! Despite consecutive quarters of plummeting rents across the city following the March 2020 onset of the COVID-19 pandemic, there seems to be a light at the end of the tunnel for certain landlords. Queens has seen its highest-priced tier of rentals — or homes priced more than $2,500 per month — recover 99%
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Scientists at Ohio State University provide evidence that members of a class of proteins called serine incorporator proteins, best known for curbing HIV infection also promote other antiviral activities that increase the production of type I interferons and proinflammatory cytokines. By promoting these signaling pathways of innate immunity, the SERINC restriction factors SERINC3 and SERINC5,
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Scientists at the Baylor College of Medicine say they have developed a technique for studying the role genes play on basic biology and disease that is easier, faster, and more efficient than current methodologies. Their drug-based genetic platform enables researchers to track genetic manipulations in the laboratory fruit fly (Drosophila melanogaster) without having to screen
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Theravance chairman and CEO Rick E. Winningham Intent on bouncing back from a pair of later-phase clinical trial failures, Theravance Biopharma said it will eliminate about 75% of its workforce—270 jobs—and slash its R&D budget next year through a restructuring that will refocus the company on respiratory drugs. Theravance said approximately 75% of the job
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Researchers at Case Comprehensive Cancer Center uncovered a potentially important role for the protein-coding gene, MYO10, in regulating genomic instability, and in tumor development and immune therapy response. Their findings suggest that levels of MYO10 may indicate which breast cancers are likely susceptible to immune checkpoint blockade (ICB). The team’s studies in cancer cells and
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Researchers at McMaster University have developed a sophisticated new tool that could help provide early warning of rare and unknown viruses in the environment and identify potentially deadly bacterial pathogens which cause sepsis, among other uses. Their findings are published in the journal Cell Reports Methods in a paper titled, “Probe design for simultaneous, targeted
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Back in the 19th century, this was J.P. Morgan’s carriage house. Now the 25-foot-wide Upper East Side home, built around 1907,  is coming back to market for $27 million. The stately digs at 118 E. 83rd St. feature a hidden pool underneath the kitchen’s oak floor, so think twice before you host any late-night tequila parties.  The
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Aging brings with it thinner bones, more fractures, and an increased likelihood of osteoporosis. One reason for these aging ailments is the impaired function of the bone-marrow stem cells, which are required for the maintenance of bone integrity. Now, researchers have shown that changes in the epigenome are one reason for the reduction in stem
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Researchers led by scientists at the National Institute of Allergy and Infectious Diseases (NIAID) have developed antibodies that can simultaneously bind to two different antigens, targeting multiple regions of the SARS-CoV-2 spike protein. These bispecific antibodies successfully neutralize the original virus as well as the Alpha, Beta, Gamma, and Delta variants. Emerging SARS-CoV-2 variants of
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Astellas Pharma has acknowledged that a fourth boy has died in the troubled Phase I/II trial through which its Astellas Gene Therapies (formerly Audentes Therapeutics) has been evaluating its adeno-associated virus (AAV) gene therapy candidate AT132 in patients with X-linked Myotubular Myopathy (XLMTM). Unlike the other three boys who all died last year in the
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