Month: September 2021

Move over Billionaires’ Row. Since the pandemic shook up the city, the superrich are ditching Midtown and heading south to Lower Manhattan. Now, properties below 34th Street are setting record after record. Amazon’s Jeff Bezos just dropped $23 million for a unit at 212 Fifth Ave. (left) where he already owns $96 million worth of
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SUMOylation is a biochemical process that peppers proteins with small ubiquitin-like modifiers (SUMOs). Earlier studies have shown SUMOylation suppresses type I interferon (IFN1) signaling that helps mobilize innate and acquired immune response against cancer. A new preclinical study led by scientists at Takeda and Jounce Therapeutics shows TAK-981, a potent and selective small-molecule inhibitor of
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Allarity Therapeutics and Lonza, a CDMO, agreed to develop and manufacture dovitinib, Allarity’s renal cell carcinoma candidate therapy. The agreement aims to begin manufacturing of dovitinib in 2022 to meet Allarity’s projected needs for bringing dovitinib to market following anticipated regulatory approvals. Dovitinib represents Allarity’s most advanced clinical asset, with possible use in other indications,
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Stanford Medicine scientists have linked insulin resistance to an increased risk of developing major depressive disorder (MDD). The researchers’ analysis of data from more than 600 participants in a major longitudinal study in the Netherlands demonstrated that three surrogate measures of insulin resistance positively predicted major depressive disorder developing over a nine-year period among adults
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The immune cells of the central nervous system, known as microglia, recognize misfolded proteins in the brain. Now, scientists have uncovered how microglia deal with the presence of α-synuclein (α-syn) fibrils. They found that microglia exposed to α-syn establish a network of intercellular connections which transfer α-syn from overloaded microglia to neighboring naive microglia. In
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Researchers led by scientists at the Baylor College of Medicine reports the discovery of a mechanism by which transcription factor KLF4 can help to organize chromatin, thus influencing gene expression. The study (“Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization”), published in Nature Communications, shows that the binding of
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The Strokes guitarist Albert Hammond Jr. has listed his Nolita apartment for $1.95 million. The common charges are a mere $695 a month. He bought the one-bedroom, two-bathroom loft at 354 Broome St. for $1.25 million in 2012 from Victoria’s Secret “Angel” Maryna Linchuk. Fiona Apple also once lived in the unit, as did artist
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Minka Kelly and Trevor Noah are back together and they’ve been spotted at 70 Vestry, where Noah has rented a unit that had been asking $52,000 a month. “They are very much a couple and Minka was actively involved in the decision to rent there,” said one of our spies. “Nope, not true,” said Noah’s spokeswoman. “Trevor
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Researchers at Johns Hopkins Medicine have discovered how a set of proteins work in tandem to build the vascular supply lines that deliver oxygen and nutrients to tumors, enabling them to survive and grow. The studies, in human cancer cells and mouse models, showed that the protein pair, peptidylarginine deiminase 4 (PADI4) and hypoxia-inducible factor
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