Month: June 2021

The ability of CRISPR, more specifically RNA-guided CRISPR activation (CRISPRa) systems, to activate genes in plants has been previously demonstrated. However, the simultaneous activation of multiple genes remains challenging. It was this aspect of the CRISPR toolbox that researchers at the University of Maryland (UMD) sought to expand. The ability to activate genes to gain
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Aging is a part of everyone’s life. It is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. Healthy aging and longevity in humans
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A team from Japan and the U.S. says it has identified the design principles for creating large “ideal” proteins from scratch, paving the way for the design of proteins with new biochemical functions. Their study (“Role of backbone strain in de novo design of complex α/β protein structures”) appears in Nature Communications. The researchers had previously
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At Quilting Daily we just can’t get enough when it comes to baby quilts. Baby quilts are one of our most popular and searched categories of quilt patterns in our library and for good reason – they’re simple, adorable, and make wonderful gifts for those that are expecting little bundles of joy. If you’re looking
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In the late 1960s, Bonucci and Anderson first reported finding small, secreted extracellular vesicles in bone cells. Over the next 20 years, through the combined use of electron microscopy, ultracentrifugation, and functional studies, other types of cells including cancer cells and immature red blood cells were also found to secrete extracellular vesicles with great biological
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The vagus (from the Latin meaning “wandering”) nerve is the longest nerve that travels from the brainstem down to the colon and controls crucial functions, such as heartrate, blood pressure, digestion, breathing, and immune response. Vagus nerve stimulation (VNS) modulates neuronal excitability and plasticity in the brain and has been used therapeutically in several neurological
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There has been a missing puzzle piece in phase separation and its role in cancer. Now, researchers at the University of North Carolina (UNC) at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center report phase separation as a driver in cancer formation. Their findings are published in the journal Nature in a paper titled,
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Editor’s Note: With so much market volatility, stay on top of daily news! Get caught up in minutes with our speedy summary of today’s must-read news and expert opinions. Sign up here! (Kitco News) – The German IFO think tank business climate reading printed at its highest level since November 2018. In addition to this,
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Finding effective therapeutic targets for cancer has never been an easy undertaking. Cancer cells can quickly become resistant to treatments through adaptation, making them notoriously tricky to defeat and highly lethal. Yet now, a team of investigators, led by scientists at Cold Spring Harbor Laboratory (CSHL) Cancer Center, have uncovered some of the underlying mechanisms
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